Atrial Fibrillation and Cancer: Pathophysiological Mechanism and Clinical Implications
Alfredo Mauriello, Adriana Correra, Vincenzo Quagliariello, Martina Iovine, Pierpaolo Di Micco, Egidio Imbalzano, Francesco Giallauria, Antonio Giordano, Vincenzo Russo, Antonello D’Andrea, Nicola Maurea
Abstract
Atrial fibrillation is the most frequent arrhythmia in elderly subjects. Cancer currently represents one of the most important causes of mortality and morbidity in the world. Often, the two pathologies coexist. Several pathophysiological mechanisms can lead to an increased risk of atrial fibrillation and cancer. Additionally, the same therapies used for cancer can increase the risk of developing atrial fibrillation. Our review aims to describe the pathophysiological mechanisms that promote the development of atrial fibrillation in cancer patients and explain the therapeutic opportunities and challenges of treating atrial fibrillation in patients with cancer.