Inhibitory effect of PPARγ on NLRP3 inflammasome activation
Ching-Chun Yang, Chih-Hsing Wu, Ta‐Chun Lin, Yi-Ning Cheng, Chin-Sung Chang, Kuo-Ting Lee, Pei-Jane Tsai, Yau-Sheng Tsai
Abstract
These results revealed an additional anti-inflammatory role for PPARγ in suppressing NLRP3 inflammasome activation through interaction with NLRP3. Thus, our study highlights that PPARγ agonism may be a therapeutic option for targeting NLRP3-related metabolic diseases.
Topics & Concepts
InflammasomeInhibitory postsynaptic potentialChemistryPeroxisome proliferator-activated receptorNeurosciencePharmacologyBiophysicsCell biologyReceptorMedicineBiologyBiochemistryInflammasome and immune disordersPeroxisome Proliferator-Activated ReceptorsEicosanoids and Hypertension Pharmacology