Microcystin-LR-induced nuclear translocation of cGAS promotes mutagenesis in human hepatocytes by impeding homologous recombination repair
Xiaofei Wang, Yuchen Zhu, Wenzun Lu, Xiaoying Guo, Liuzeng Chen, Ning Zhang, Shaopeng Chen, Chunmei Ge, Shengmin Xu
Topics & Concepts
Homologous recombinationBiologyChromosomal translocationCytoplasmCell biologyMolecular biologyHomologous chromosomeDNA repairChemistryGeneticsGeneinterferon and immune responsesUbiquitin and proteasome pathwaysCRISPR and Genetic Engineering