A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models
Weijin Wang, Qiuzhi Zhou, Tao Jiang, Shihong Li, Jinwang Ye, Jie Zheng, Xin Wang, Yanchao Liu, Minmin Deng, Dan Ke, Qun Wang, Yipeng Wang, Jian‐Zhi Wang
Abstract
, which provides a promising drug candidate for AD and the related tauopathies.
Topics & Concepts
In vivoProteolysisHEK 293 cellsChemistryCell biologyTransgeneGenetically modified mouseNeuroscienceUbiquitin ligaseTau proteinSynaptic plasticityProteasomeUbiquitinPharmacologyBiologyAlzheimer's diseaseMedicineBiochemistryInternal medicineReceptorDiseaseBiotechnologyEnzymeGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis