Visible-Light-Mediated Deacylated Alkynylation of Unstrained Ketone
Hao Wu, Shuguang Chen, Dengmengfei Xiao, Feng Li, Kaiyuan Zhou, Xiaocui Yin, Chunni Liu, Xinwei He, Yongjia Shang
Abstract
Deconstructive alkynylation of an unstrained ketone catalyzed by an organic photocatalyst under blue light irradiation is reported for the first time. A broad substrate scope with up to 63 examples, excellent functional group tolerance, and gram scale reaction demonstrated the practicality of this novel alkynylation method. The dihydroquinazolinone derivative of trifluoroacetophenone had been proved to have potential as a novel trifluoromethylation reagent after working well for the trifluoromethylation reaction with various alkynyl bromides.
Topics & Concepts
AlkynylationChemistryTrifluoromethylationKetoneReagentSubstrate (aquarium)Functional groupPhotocatalysisCombinatorial chemistryCatalysisDerivative (finance)Visible spectrumScope (computer science)PhotochemistryOrganic chemistryOptoelectronicsComputer scienceTrifluoromethylFinancial economicsProgramming languageAlkylPolymerEconomicsGeologyPhysicsOceanographyFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods