Inter-Individual Variation and Cardioprotection in Anthracycline-Induced Heart Failure
Nadine Norton, Raegan M. Weil, Pooja Advani
Abstract
Anthracyclines are one of the most widely used and effective chemotherapies in oncology, but their most important side effect is the cumulative, dose-related cardiotoxicity leading to congestive heart failure in ~5% of individuals. Methodology and pharmacogenetic studies for predicting which individuals are at high risk and subsequently the development of targeted and individualized cardioprotective plans are beginning to make progress. Here, we review current putative risk genes and variants, the strength of evidence for each genetic association and the interaction between risk genes, in the context of known clinical risk factors and potential novel cardioprotective strategies.
Topics & Concepts
MedicineCardiotoxicityHeart failureAnthracyclineCardioprotectionContext (archaeology)PharmacogeneticsInternal medicineBioinformaticsPharmacologyCardiologyOncologyIntensive care medicineGeneCancerChemotherapyGenotypeGeneticsMyocardial infarctionBreast cancerPaleontologyBiologyChemotherapy-induced cardiotoxicity and mitigationCancer-related cognitive impairment studiesPARP inhibition in cancer therapy