Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition
Sérgio Alexandre Alcântara dos Santos, Ana Carolina Lima Camargo, Flávia Bessi Constantino, Ketlin T. Colombelli, Luiz Marcos Frediani Portela, Matheus Naia Fioretto, José Cavalcante Souza Vieira, Pedro de Magalhães Padilha, Mateus Betta de Oliveira, Sérgio Luís Felisbino, Robson Francisco Carvalho, Luís Antônio Justulin
Abstract
analysis that identified commonly deregulated proteins in the ventral prostate of old rats submitted to MM with a mouse model and patients with prostate cancer. In conclusion, our results demonstrated that estrogenic signaling pathways, endoplasmic reticulum functions, energy metabolism, and molecular sensors of protein folding and Ca2+ homeostasis, besides histone, and RAS-GTPase family appear to be involved in this process. Knowledge of these factors may raise discussions regarding the role of maternal dietary intervention as a public policy for the lifelong prevention of chronic diseases.