Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
Hua Guo, Ben Hu, Hao-Rui Si, Yan Zhu, Wei Zhang, Bei Li, Ang Li, Rong Geng, Haofeng Lin, Xing‐Lou Yang, Peng Zhou, Zheng‐Li Shi
Abstract
, Malayan pangolin, and use it as an entry receptor, except for ACE2 from humans. However, it contains a short deletion and has different key residues responsible for ACE2 binding. In addition, we showed that none of the known viruses in bat SARSr-CoV-2 lineage discovered uses human ACE2 as efficiently as the pangolin-derived SARSr-CoV-2 or some viruses in the SARSr-CoV-1 lineage. Therefore, further systematic and longitudinal studies in bats are needed to prevent future spillover events caused by SARSr-CoVs or to understand the origin of SARS-CoV-2 better.
Topics & Concepts
Lineage (genetic)BiologyPangolinPhylogenetic treePhylogeneticsCoronavirusVirologyGeneticsSequence alignmentEvolutionary biologyBetacoronavirusConserved sequencePsittaciformesGeneZoologyPeptide sequenceCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)EcologyPathologyMedicineSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesCOVID-19 Clinical Research Studies