A simple method for <i>N</i>-arylation of secondary amides/amines through a NaH-initiated aryne generation strategy
Yuanrui Jiang, Wenjing Zhu, Jiawen Huang, Fan Luo, Xiaobei Chen, Chunhui Fang, Xin Chen, Shihui Liu, Yanwei Hu, Shilei Zhang
Abstract
A very simple and practical method has been uncovered for N -arylation of many sets of secondary amides/amines.
Topics & Concepts
ChemistryAryneSimple (philosophy)Combinatorial chemistryOrganic chemistryPhilosophyEpistemologyCyclization and Aryne ChemistryCatalytic Cross-Coupling ReactionsChemical synthesis and alkaloids