Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis
Martina Di Francesco, Sean K. Bedingfield, Valentina Di Francesco, Juan M. Colazo, Fang Yu, Luca Ceseracciu, Elena Bellotti, Daniele Di Mascolo, Miguel Ferreira, Lauren E. Himmel, Craig L. Duvall, Paolo Decuzzi
Abstract
) decreased the expression of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, and matrix metalloproteinase (MMP)-13 by approximately half compared to free DEX at 4 weeks post-treatment. DEX-μPL also reduced load-induced histological changes in the articular cartilage and synovial tissues relative to saline or free DEX. In sum, the μPLs provide sustained drug release along with the capability to precisely control particle geometry and mechanical properties, yielding long-lasting benefits in overload-induced OA. This work motivates further study and development of particles that provide combined pharmacological and mechanical benefits.