Warburg-like Metabolic Reprogramming in Aging Intestinal Stem Cells Contributes to Tissue Hyperplasia
Otto Morris, Hansong Deng, Christine Tam, Heinrich Jasper
Abstract
and enhances ISC hyperplasia. Our data identify a critical mechanism for metabolic adaptation of tissue SCs and reveal how its decline sets aging SCs on a metabolic trajectory reminiscent of that seen upon oncogenic transformation.
Topics & Concepts
ReprogrammingStem cellCell biologyWarburg effectBiologyMetabolismGlycolysisCellGeneticsBiochemistryCancer, Hypoxia, and MetabolismIon Transport and Channel Regulation3D Printing in Biomedical Research