An Unprecedented FeMo<sub>6</sub>@Ce‐Uio‐66 Nanocomposite with Cascade Enzyme‐Mimic Activity as Colorimetric Sensing Platform
Zhibo Tong, Jingquan Sha, Dingzhou Liu, Mingqi Xu
Abstract
Abstract Introducing the idea of integrated design and cascade activity into nanozyme, the novel integrated nanozymes (INAzymes), FeMo 6 @Ce‐Uio‐66 (FC‐66(n)), were designed and synthesized by encapsulating iron‐based polyoxometalates (FeMo 6 ) into the ceria‐based metal–organic framework (Ce‐Uio‐66). Due to the oxygen‐driven reversible Ce 3+ /Ce 4+ couple sites, the “Fenton‐like” effect by iron centers, the “nanoscale proximity” effects by nanocages, and their synergistic effects, FC‐66(n) as INAzymes exhibit elegant cascade enzyme‐mimic activities (oxidase‐, peroxidase‐, and Fenton‐like activity), which realizes INAzyme activities based on polyoxometalates based metal–organic framework (POMOFs). By employing dopamine (DA) detection as a model reaction, a high‐efficient fluorescent “turning‐on‐enhanced” platform under near neutral conditions was established.