Targeting of proteins to the twin‐arginine translocation pathway
Tracy Palmer, Phillip J. Stansfeld
Abstract
The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation.
Topics & Concepts
Twin-arginine translocation pathwayBiologyTransloconTransport proteinChromosomal translocationProtein targetingCell biologyArginineSignal peptideSignal recognition particleProtein Sorting SignalsOrganelleSignal peptidaseMembrane transport proteinMembrane proteinBiochemistryPeptide sequenceMembraneAmino acidGeneRNA and protein synthesis mechanismsBacteriophages and microbial interactionsBacterial Genetics and Biotechnology