Amyloid Fibril Formation of Arctic Amyloid-β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain
Xueying Zhong, Rakesh Kumar, Yu Wang, Henrik Biverstål, Caroline Ingeborg Jegerschöld, Philip J.B. Koeck, Jan Johansson, Axel Abelein, Gefei Chen
Abstract
aggregation, resulting in both delayed fibril formation kinetics and altered fibril structure.
Topics & Concepts
FibrilChemistryBiophysicsProtein filamentPeptideThioflavinAmyloid (mycology)Protein aggregationFiber diffractionProtein foldingNucleationBiochemistryBiologyAlzheimer's diseaseDiseaseOpticsX-ray crystallographyMedicineOrganic chemistryPathologyInorganic chemistryDiffractionPhysicsAlzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingProtein Structure and Dynamics