Late-stage C(sp<sup>2</sup>)–H and C(sp<sup>3</sup>)–H glycosylation of <i>C</i>-aryl/alkyl glycopeptides: mechanistic insights and fluorescence labeling
Jun Wu, Nikolaos Kaplaneris, Shao‐Fei Ni, Felix Kaltenhäuser, Lutz Ackermann
Abstract
-aryl glycosides, while enabling the assembly of fluorescent-labeled glycoamino acids. The C-H activation approach represents an expedient and efficient strategy for peptide late-stage diversification in a programmable as well as chemo-, regio-, and diastereo-selective fashion.
Topics & Concepts
GlycosylationChemistryGlycopeptideArylFluorescenceAlkylAmino acidPalladiumPeptideStereochemistryCombinatorial chemistryCatalysisBiochemistryOrganic chemistryPhysicsQuantum mechanicsAntibioticsCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsFluorine in Organic Chemistry