Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells
Yali He, Chuanhe Yang, Yinan Wang, Joshua R. Sacher, Michelle Sims, Lawrence M. Pfeffer, Duane D. Miller
Topics & Concepts
TemozolomideChemistryCancer researchIn vivoIn vitroProtein subunitSMARCB1DacarbazineMelanomaPharmacologyGlioblastomaChromatin remodelingMedicineChromatinDNABiologyBiochemistryBiotechnologyGeneChromatin Remodeling and CancerProtein Degradation and InhibitorsCancer Mechanisms and Therapy