Novel 5-(Arylideneamino)-1<i>H</i>-Benzo[<i>d</i>]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies
Sardar Ali, Mumtaz Ali, Ajmal Khan, Saeed Ullah, Muhammad Waqas, Ahmed Al‐Harrasi, Abdul Latif, Manzoor Ahmad, Muhammad Saadiq
Abstract
: 343.10 ± 1.62 μM). Molecular docking revealed important interactions with the enzyme, thereby supporting the experimental findings.
Topics & Concepts
ImidazoleIC50ChemistryThiolStereochemistryAcarboseDocking (animal)EnzymeIn vitroBiochemistryMedicineNursingSynthesis and biological activityEnzyme function and inhibitionCarbohydrate Chemistry and Synthesis