A reservoir of stem-like CD8 <sup>+</sup> T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response
Kelli A. Connolly, Manik Kuchroo, Aarthi Venkat, Achia Khatun, Jiawei Wang, Ivana William, Noah I. Hornick, Brittany Fitzgerald, Martina Damo, Moujtaba Y. Kasmani, Can Cui, Eric Fagerberg, Isabel Monroy, Amanda Hutchins, Julie F. Cheung, Gena G. Foster, Dylan L. Mariuzza, Mursal Nader, Hongyu Zhao, Weiguo Cui, Smita Krishnaswamy, Nikhil S. Joshi
Abstract
reservoir has a critical function in sustaining antitumor T cells during tumor development and in protecting them from the terminal differentiation that occurs in the TME.
Topics & Concepts
Lymph nodeImmune systemCD8LymphBiologyCytotoxic T cellCancer researchImmunologyPathologyMedicineIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and Interaction