Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia
Aya Futamura, Ryo Suzuki, Yunoshin Tamura, Hiroshi Kawamoto, Mari Ohmichi, Noriko Hino, Yuichi Tokumaru, Sora Kirinuki, Tetsuaki Hiyoshi, Takeshi Aoki, Daiji Kambe, Dai Nozawa
Topics & Concepts
OrexinOrexin receptorChemistryAntagonistLipophilicityPharmacologyPolysomnogramReceptorStereochemistryChemical synthesisInternal medicineBiochemistryNeuropeptideIn vitroMedicinePolysomnographyApneaSleep and Wakefulness ResearchSleep and related disordersPhotochromic and Fluorescence Chemistry