Sequence and structure-guided discovery of a novel NADH-dependent 7β-hydroxysteroid dehydrogenase for efficient biosynthesis of ursodeoxycholic acid
Bin Huang, Kai Yang, Charles Amanze, Zhen Yan, Hongbo Zhou, Xueduan Liu, Guanzhou Qiu, Weimin Zeng
Topics & Concepts
Hydroxysteroid dehydrogenaseCofactorChemistryUrsodeoxycholic acidThermostabilityHydroxysteroid DehydrogenasesBiochemistryDehydrogenaseEnzymeEnzyme kineticsBiosynthesisOxidoreductaseActive siteAldose Reductase and TaurineHormonal Regulation and HypertensionEnzyme Catalysis and Immobilization