Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
Xiaqiu Qiu, Yuan‐Qing Li, Bin Yu, Jie Ren, Huidan Huang, Min Wang, Hong Ding, Zhiyu Li, Jubo Wang, Jinlei Bian
Topics & Concepts
ChemistryMyeloid leukemiaCyclin-dependent kinaseKinaseCyclin-dependent kinase 9ProteolysisXIAPCell biologyCancer researchBiochemistryCyclin-dependent kinase 2ApoptosisCell cycleProtein kinase ABiologyProgrammed cell deathEnzymeCaspaseProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments