The renin angiotensin aldosterone system
Hannah Triebel, Hayo Castrop
Abstract
In this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the major effects of the RAAS. For the effects of the RAAS, we focus on the role of the RAAS in the regulation of volume homeostasis and vascular tone, as major determinants of arterial blood pressure.
Topics & Concepts
Renin–angiotensin systemHomeostasisAldosteroneBlood pressureInternal medicineBlood volumeMedicineCardiologyEndocrinologyRenin-Angiotensin System StudiesHormonal Regulation and HypertensionReceptor Mechanisms and Signaling