Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway
Chennian Xu, Lingheng Kong, Peng Ding, Yang Liu, Zhenge Fan, Erhe Gao, Jian Yang, Li-Fang Yang
Topics & Concepts
ATG5MelatoninProtein kinase BPressure overloadPI3K/AKT/mTOR pathwayInternal medicineEndocrinologyAutophagyMedicineMuscle hypertrophyPhospholambanLY294002Heart failureBiologyApoptosisSignal transductionCell biologyCardiac hypertrophyBiochemistryGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy