Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation
Ana Xu, Feng He, Xiangna Zhang, Xiaoyang Li, Yingying Ran, Chao Wei, C. James Chou, Rui Zhang, Jingde Wu
Topics & Concepts
TacrineChemistryHistone deacetylaseLead compoundIC50Inhibitory postsynaptic potentialAchéPotencyAntioxidantStereochemistryCholinesterasePharmacologyBiochemistryAcetylcholinesteraseCombinatorial chemistryIn vitroEnzymeHistoneNeuroscienceMedicineBiologyGeneCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsComputational Drug Discovery Methods