Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke
Feifei Ma, Ping Sun, Xuejing Zhang, Milton H. Hamblin, Ke‐Jie Yin
Abstract
suppresses BBB pathologies after ischemic stroke. Elucidating the molecular mechanisms of miR-15a/16-1-mediated BBB dysfunction may enable the discovery of new therapies for ischemic stroke.
Topics & Concepts
Blood–brain barrierEndotheliumIschemic strokeStroke (engine)MedicineEndothelial dysfunctionCancer researchIschemiaInternal medicineCentral nervous systemEngineeringMechanical engineeringBarrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments