Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway
Jingyi Luo, Pengbo Sun, Yangyang Wang, Yang Chen, Yaoyun Niu, Yipei Ding, Naihan Xu, Yaou Zhang, Weidong Xie
Topics & Concepts
DapagliflozinAMPKSteatosisPI3K/AKT/mTOR pathwayFatty liverAMP-activated protein kinasePharmacologyIn vivoLipid metabolismDownregulation and upregulationAcetyl-CoA carboxylaseBeta oxidationChemistryProtein kinase AEndocrinologyBiologyInternal medicineKinaseDiabetes mellitusFatty acidBiochemistrySignal transductionPyruvate carboxylaseType 2 diabetesMedicineEnzymeDiseaseGeneBiotechnologyPancreatic function and diabetesMetabolism, Diabetes, and CancerLiver Disease Diagnosis and Treatment