Efficient selective targeting of <i>Candida</i> CYP51 by oxadiazole derivatives designed from plant cuminaldehyde
Rania Hamdy, Alshaimaa M. Hamoda, Mariam Al-Khalifa, Varsha Menon, Raafat El‐Awady, Sameh S. M. Soliman
Abstract
Effective targeting of Candida CYP51 enzyme by oxadiazole derivatives following iterated lead optimization using plant cuminaldehyde as a scaffold.
Topics & Concepts
OxadiazoleChemistryAntifungalBiologyOrganic chemistryMicrobiologyComputational Drug Discovery MethodsSynthesis and biological activityAntifungal resistance and susceptibility