Three-Component Reactions of Alkynone <i>o</i>-Methyloximes, Element Selenium, and Boronic Acids Leading to 4-Organoselenylisoxazoles
Jian Wu, Ye‐Fei Yang, Xiaobo Huang, Wenxia Gao, Yunbing Zhou, Miaochang Liu, Huayue Wu
Abstract
We report an Ag-catalyzed one-pot three-component reaction of alkynone o-methyloxime, element selenium, and boronic acid, providing a facile route to selenated isoxazole product. This protocol features high efficiency, wide substrate scope, and the use of selenium powder as the selenium source.
Topics & Concepts
SeleniumBoronic acidSubstrate (aquarium)ChemistryScope (computer science)Component (thermodynamics)IsoxazoleCombinatorial chemistryOrganic chemistryComputer scienceBiologyThermodynamicsProgramming languageEcologyPhysicsOrganoselenium and organotellurium chemistrySulfur-Based Synthesis TechniquesCatalytic Alkyne Reactions