HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia
Xinyan Li, Mengshen Wang, Su Li, Yuqiong Chen, Mozhi Wang, Zhonghua Wu, Xiangyu Sun, Litong Yao, Haoran Dong, Yongxi Song, Yingying Xu
Abstract
This work elucidates the molecular mechanism by which MRPL52 mediates hypoxia-induced apoptotic resistance and metastatic initiation of breast cancer, and provides new insights into the interplay between cancer and the tumor microenvironment.
Topics & Concepts
Cancer researchBiologyMetastasisGene knockdownBreast cancerMitochondrionCancerCell biologyMolecular biologyApoptosisBiochemistryGeneticsRNA modifications and cancerMitochondrial Function and PathologyCancer, Hypoxia, and Metabolism