Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer
Shilong Zhang, Yuqin Mao, Zhengyan Zhang, Zhanming Li, Chao‐Yue Kong, Huiling Chen, Pei‐Ran Cai, Bing Han, Ye Tao, Li‐Shun Wang
Abstract
Pectin facilitated the anti-PD-1 mAb efficacy in CRC via regulating the T cell infiltration in the tumor microenvironment, which was potentially mediated by the metabolite butyrate.
Topics & Concepts
Gut floraColorectal cancerImmune systemFlow cytometryBifidobacteriumTumor microenvironmentImmunotherapyImmunohistochemistryBiologyHumanized mouseCancer researchImmunologyMedicineCancerInternal medicineLactobacillusBacteriaGeneticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disorders