Structurally Diverse Alkaloids with Anti-Renal-Fibrosis Activity from the Centipede <i>Scolopendra subspinipes mutilans</i>
Bin‐Yuan Hu, Wu‐Mei Sun, Cheng-Tian Tao, Sheng‐Hong Li, Qiang Gao, Yong‐Ming Yan, Yong‐Xian Cheng
Abstract
Twelve new alkaloids, scolopenolines A–L ( 1 – 7, 9 – 11, 13, 14 ), along with six known analogues, were isolated from Scolopendra subspinipes mutilans, identified by analysis of spectroscopic data and quantum chemical and computational methods. Scolopenoline A ( 1 ), a unique guanidyl-containing C 14 quinoline alkaloid, features a 6/6/5 ring backbone. Scolopenoline B ( 2 ) is a novel sulfonyl-containing heterodimer comprising quinoline and tyramine moieties. Scolopenoline G ( 7 ) presents a rare C 12 quinoline skeleton with a 6/6/5 ring system. Alkaloids 1, 8, 10, and 15 – 18 display anti-inflammatory activity, while 10 and 16 – 18 also exhibit anti-renal-fibrosis activity. Drug affinity responsive target stability and RNA-interference assays show that Lamp2 might be a potentially important target protein of 16 for anti-renal-fibrosis activity.