Balancing Positive and Negative Selection: <i>In Vivo</i> Evolution of Candida lusitaniae <i>MRR1</i>
Elora G. Demers, Jason Stajich, Alix Ashare, Patricia Occhipinti, Deborah A. Hogan
Abstract
infection revealed the selection for both high and low Mrr1 activity. Our studies reveal trade-offs between high Mrr1 activity, which confers resistance to the commonly used antifungal fluconazole, host antimicrobial peptides, and bacterial products, and resistance to hydrogen peroxide. This work suggests that spatial or temporal differences within chronic infections can support a large amount of dynamic and parallel evolution and that Mrr1 activity is under both positive and negative selective pressure to balance different traits that are important for microbial survival.
Topics & Concepts
BiologyMicrobiologyPathogenSelection (genetic algorithm)Computer scienceArtificial intelligenceAntifungal resistance and susceptibilityFungal Infections and StudiesReproductive tract infections research