Inhibition of PCSK9 prevents and alleviates cholesterol gallstones through PPARα-mediated CYP7A1 activation
Zhenmei Chen, Weiqing Shao, Yitong Li, Xiandi Zhang, Yan Geng, Xiaochen Ma, Baorui Tao, Yue Ma, Chenhe Yi, Bo Zhang, Rui Zhang, Jing Lin, Jinhong Chen
Topics & Concepts
PCSK9Cholesterol 7 alpha-hydroxylaseCholesterolKexinProprotein convertaseInternal medicineEndocrinologyGallstonesHMG-CoA reductasePharmacologyMedicineChemistryLDL receptorLipoproteinBiochemistryEnzymeReductaseDrug Transport and Resistance MechanismsCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health