Newly Discovered Antimicrobial Peptide Scyampcin <sub>44–63</sub> from Scylla paramamosain Exhibits a Multitargeted Candidacidal Mechanism <i>In Vitro</i> and Is Effective in a Murine Model of Vaginal Candidiasis
Ying Zhou, Xiangyu Meng, Fangyi Chen, Ming Xiong, Weibin Zhang, Ke-Jian Wang
Abstract
The emergence of azole-resistant and biofilm-forming Candida spp. contributes to the constantly increasing incidence of vulvovaginal candidiasis. It is imperative to explore new antifungal drugs or potential substituents, such as antimicrobial peptides, to alleviate the serious crisis caused by resistant fungi.
Topics & Concepts
AzoleAntimicrobialMicrobiologyIn vitroAntifungalAntimicrobial peptidesPeptideBiofilmBiologyChemistryBacteriaBiochemistryGeneticsAntimicrobial Peptides and ActivitiesAntifungal resistance and susceptibilityReproductive tract infections research