Discovery of a novel rice-derived peptide with significant anti-gout potency
Naixin Liu, Buliang Meng, Lin Zeng, Saige Yin, Yan Hu, Shanshan Li, Fu Yang, Xinping Zhang, Chun Xie, Longjun Shu, Meifeng Yang, Ying Wang, Xinwang Yang
Abstract
) induced a significant reduction in serum uric acid levels in hyperuricemic mice via suppressing xanthine oxidase activity and urate transporter 1 expression, as well as alleviated renal damage through inhibiting the activation of NLRP3 inflammasome. In addition, RDP2 can also alleviate paw swelling and inflammatory reactions in mice after subcutaneous injection of monosodium urate crystals. As mentioned above, we obtained a novel peptide which could work through all stages of gout, not only reducing uric acid levels and renal damage in hyperuricemic mice, but also alleviating inflammatory responses associated with acute gout attack, and thus provided a new peptide molecular template for the development of anti-gout drugs.