Structure-directed expansion of biphenyl-pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with significantly improved potency and safety
Limin Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen
Topics & Concepts
Reverse transcriptaseChemistryPotencyIC50Nucleoside Reverse Transcriptase InhibitorStereochemistryEnzymeMutantDocking (animal)EC50In vitroBiochemistryRNAMedicineGeneNursingHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment