Iminoamido chelated iridium(III) and ruthenium(II) anticancer complexes with mitochondria-targeting ability and potential to overcome cisplatin resistance
Lihua Guo, Pengwei Li, Zhihong Jing, Yuwen Gong, Kangning Lai, Hanxiu Fu, Heqian Dong, Zhihao Yang, Zhe Liu
Topics & Concepts
ChemistryCytotoxicityHeLaRutheniumCisplatinApoptosisIridiumLigand (biochemistry)Reactive oxygen speciesA549 cellCancer cellMetalChelationCombinatorial chemistryStereochemistryCellBiochemistryCancerIn vitroReceptorOrganic chemistryChemotherapyCatalysisInternal medicineMedicineSurgeryMetal complexes synthesis and propertiesMagnetism in coordination complexesMetal-Organic Frameworks: Synthesis and Applications