Litcius/Paper detail

Rh(<scp>iii</scp>)-catalyzed selective mono- and dual-functionalization/cyclization of 1-aryl-5-aminopyrazoles with iodonium ylides

Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang

2023Chemical Communications31 citationsDOI

Abstract

An efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as a single coupling partner was demonstrated, in which fused benzodiazepine skeletons were obtained in excellent yields. This method greatly improved an effective approach to dual C-H unsymmetrical functionalization.

Topics & Concepts

Surface modificationCatalysisArylChemistryCombinatorial chemistryDual functionDual roleDual (grammatical number)Medicinal chemistryOrganic chemistryPhysical chemistryEngineering drawingLiteratureContouringEngineeringArtAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms