Recent Advances in Synthetic Methods for Radioiodination
Emmanuelle Dubost⧫, Holly McErlain, Victor Babin, Andrew Sutherland, Thomas Cailly
Abstract
Organic compounds bearing radioisotopes of iodine are widely used for biological research, diagnostic imaging, and radiotherapy. Early reported synthetic methods for the incorporation of radioiodine have generally involved high temperature reactions or strongly oxidizing conditions. To overcome these limitations and to cope with the demand for novel radioiodinated probes, there has been a surge in the development of new synthetic methodology for radioiodination. This synopsis describes the key transformations developed recently.
Topics & Concepts
Oxidizing agentBiochemical engineeringIodineChemistryCombinatorial chemistryComputer scienceRadiochemistryEngineeringOrganic chemistryRadiopharmaceutical Chemistry and ApplicationsChemical Reactions and IsotopesMedical Imaging Techniques and Applications