Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
Huiping Liao, Yuchao Zhang, Wei Guo, Xi Wang, Hailong Wang, Haocheng Ye, Kaichun Wu, Yuhang Zhang, Lingyun Guo, Yufei Zhu, Yongli Guo, Landian Hu, Gang Liu, Xiangyin Kong
Abstract
This study revealed the microbial compositions in children with bacterial meningitis who were treated with antibiotics and made a comprehensive comparison between blood and CSF specimens for the risk and prognosis assessment. We found that microbiome signatures could distinguish patient subsets in the children and were correlated with the CRP level in blood and granulocyte percentage in CSF. The compositional changes in representative microbiota constituents could provide guidance for clinical monitoring and antibiotic intervention.
Topics & Concepts
Cerebrospinal fluidMicrobiomeBacterial meningitisInflammationMeningitisAntibioticsMedicineImmunologyAntibiotic therapyMicrobiologyPathologyBiologyPediatricsBioinformaticsBacterial Infections and VaccinesPneumonia and Respiratory InfectionsClostridium difficile and Clostridium perfringens research