Cardiac cell type–specific gene regulatory programs and disease risk association
James D. Hocker, Olivier Poirion, Fugui Zhu, Justin Buchanan, Kai Zhang, Joshua Chiou, Tsui‐Min Wang, Qingquan Zhang, Xiaomeng Hou, Yang Eric Li, Yanxiao Zhang, Elie N. Farah, Allen Wang, Andrew D. McCulloch, Kyle J. Gaulton, Bing Ren, C. Neil, Sebastian Preißl
Abstract
expression and action potential repolarization. Overall, this atlas of human cardiac cCREs provides the foundation for illuminating cell type-specific gene regulation in human hearts during health and disease.
Topics & Concepts
Cell typeRegulator geneDiseaseRegulatory sequenceGeneGene regulatory networkCellComputational biologyBiologyRegulation of gene expressionMedicineGeneticsBioinformaticsGene expressionPathologyRNA Research and SplicingRNA and protein synthesis mechanismsCRISPR and Genetic Engineering