Litcius/Paper detail

Targeting replication stress in cancer therapy

Alexandre André Balieiro Anastácio da Costa, Dipanjan Chowdhury, Geoffrey I. Shapiro, Alan D. D’Andrea, Panagiotis A. Konstantinopoulos

2022Nature Reviews Drug Discovery354 citationsDOIOpen Access PDF

Topics & Concepts

Wee1DNA damageCHEK1BiologyGenome instabilityPoly ADP ribose polymeraseCancer researchKinaseDNA repairCancerCell cycle checkpointCell cyclePolymeraseDNACell biologyGeneticsCyclin-dependent kinase 1DNA Repair MechanismsPARP inhibition in cancer therapyEpigenetics and DNA Methylation