IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors
Andreas Hombach, Markus Barden, Lisa Hannappel, Markus Chmielewski, Gunter Rappl, Agapios Sachinidis, Hinrich Abken
Topics & Concepts
Interleukin 12Cytotoxic T cellChimeric antigen receptorInterleukin 21AntigenCD28NK-92BiologyAntigen-presenting cellCell biologyImmunologyCD8Cancer researchT cellImmune systemIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology