Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU
Yujie Cai, Jin Yao, Yingxuan Liu, Dandan Zhang, Zheng Gong, Li Li, Xiongjin Chen, Chunmei Liang, Sifan Feng, Jiongtong Lu, Qinjie Qiu, Zhixiong Lin, Yan Wang, Lili Cui
Abstract
The findings of the present study revealed that the expression of circUBE2K, which combines with HNRNPU to form the circUBE2K/HNRNPU complex, is increased in microglia after external stress, thus regulating the expression of the parental gene UBE2K and mediating the abnormal activation of microglia to induce neuroinflammation, promoting the development of MDD. These results indicate that circ-UBE2K plays a newly discovered role in the pathogenesis of depression.
Topics & Concepts
Depression (economics)EpigeneticsMechanism (biology)PathogenesisDiseaseGeneMedicineMechanism of actionBioinformaticsNeuroscienceBiologyGeneticsInternal medicineIn vitroEpistemologyPhilosophyMacroeconomicsEconomicsCircular RNAs in diseasesMicroRNA in disease regulationNuclear Receptors and Signaling