Highly selective hydrolysis of amides <i>via</i> electroreduction
Jin-Yu He, Yanzhao Wang, Wenxi Duan, Jiarong Li, Hao Xu, Cuiju Zhu
Abstract
Deprotection of amides is a virtually universal transformation in organic synthesis, often employing traditional active reductants. Herein, we describe a sustainable electrocatalytic hydrolysis of amides utilizing water as the hydrogen source.
Topics & Concepts
HydrolysisChemistryCombinatorial chemistryOrganic chemistryChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic Chemistry