Hyaluronidase-trigger nanocarriers for targeted delivery of anti-liver cancer compound
Junxin Xu, Siling Chen, Jianmei Yang, Zhengquan Nie, Junnan He, Yong Zhao, Yong Zhao, Xiaoqing Liu, Jin Zhang, Yan Zhao, Yan Zhao
Abstract
HA/(MI) 7 -β-CD NCs exhibits HA receptor-mediated targeting and disassembly properties under HAase stimulation, which was utilized to trap, targeted deliver and controlled release of anti-liver cancer compound CSL.
Topics & Concepts
NanocarriersLiver cancerCytotoxicityCancer cellChemistryDoxorubicinCD44Cancer researchPharmacologyDrug deliveryCancerChemotherapyMedicineCellBiochemistryIn vitroInternal medicineHepatocellular carcinomaOrganic chemistryGlycosylation and Glycoproteins ResearchNanoparticle-Based Drug DeliveryProteoglycans and glycosaminoglycans research