Inhibition of Antiviral Innate Immunity by <i>Avibirnavirus</i> VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation
Tingjuan Deng, Boli Hu, Xingbo Wang, Lulu Lin, Jianwei Zhou, Yuting Xu, Yan Yan, Xiaojuan Zheng, Jiyong Zhou
Abstract
Type I interferon plays a critical role in the host response against virus infection, including Avibirnavirus. However, many viruses have developed multiple strategies to antagonize the innate host antiviral immune response during coevolution with the host. In this study, we first identified that K33-linked polyubiquitination of lysine-155 of TRAF3 enhances the interaction with TBK1, which positively regulates the host IFN immune response.
Topics & Concepts
IRF3Innate immune systemTANK-binding kinase 1InterferonImmune systemCoevolutionBiologyImmunityHost (biology)UbiquitinVirologyCell biologyImmunologySignal transductionGeneGeneticsPaleontologyProtein kinase CMitogen-activated protein kinase kinaseViral Infections and Vectorsinterferon and immune responsesViral Infections and Immunology Research