Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles
Fei Gong, Huihui Hu, Ying Ouyang, Zhengzheng Liao, Ying Kong, Jinfang Hu, Hua He, Ying Zhou
Topics & Concepts
CYP2C19TacrolimusVoriconazolePharmacologyCYP3A5PharmacokineticsPhysiologically based pharmacokinetic modellingCYP3A4PharmacogeneticsDosingMedicineDrug interactionChemistryGenotypeInternal medicineTransplantationCytochrome P450MetabolismBiochemistryAntifungalGeneDermatologyRenal Transplantation Outcomes and TreatmentsPharmacogenetics and Drug MetabolismPharmacological Effects and Toxicity Studies