Synthesis of 2H-pyrroles via iron catalyzed dehydrogenative coupling and C–C bond cleavage
Suya Cui, Xiao‐Yun Wu, Wei Ma, Weijun Tang, Huaming Sun, Jianliang Xiao, Dong Xue, Chao Wang
Abstract
Iron catalyzed coupling of β-amino alcohols with allylic alcohols for the synthesis of 3,4-dihydro-2H-pyrrole derivatives has been developed. Mechanistic studies suggest that the reaction involves iron catalyzed dehydrogenative coupling and C–C bond cleavage processes.
Topics & Concepts
CatalysisAllylic rearrangementCleavage (geology)Bond cleavageChemistryPyrroleCoupling (piping)Coupling reactionCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryMaterials scienceFracture (geology)MetallurgyComposite materialAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis