Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets
Harriet Lea‐Banks, Meaghan A. O’Reilly, Clement Hamani, Kullervo Hynynen
Abstract
Background: Targeted neuromodulation is a valuable technique for the study and treatment of the brain. Using focused ultrasound to target the local delivery of anesthetics in the brain offers a safe and reproducible option for suppressing neuronal activity.
Topics & Concepts
MicrobubblesNeuromodulationUltrasoundBarbituratePentobarbitalDrug deliveryBlood–brain barrierMedicineNeurosciencePharmacologyChemistryBiomedical engineeringAnesthesiaCentral nervous systemInternal medicinePsychologyOrganic chemistryRadiologyUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingUltrasound and Cavitation Phenomena